Duke Blue Devils forward Cameron Boozer and UConn senior center Tarris Reed Jr. headline the marquee Sweet 16 matchup. With Caleb Foster returning, Duke's defense ranks fourth nationally, and TST recommends betting on Duke -5 over UConn to advance to the Final Four.
Duke vs UConn Sweet 16: TST Best Bets
The 2026 NCAA Tournament features a heavyweight Sweet 16 clash between No. 1 Duke and No. 2 UConn, with TST highlighting Duke as a top betting option.