Nottingham Forest defeated Fenerbahçe 3-0 in their first leg, with Vítor Pereira making an immediate impact in his debut as manager. The English side, despite struggling in the Premier League, has not conceded a goal in their last three European home matches.
Meanwhile, Stuttgart dominated Celtic with a 4-1 victory at Celtic Park, spoiling caretaker boss Martin O'Neill's 1,000th career game. Other teams with first-leg leads include Genk (3-1 over Dinamo Zagreb) and Bologna (1-0 up against Brann).