Braden Smith added 15 points and eight assists while Fletcher Loyer and Omer Mayer each scored 18 points for Purdue (22-5, 12-4 Big Ten). The Boilermakers took control early with an 11-4 run to build a 26-14 lead and never looked back, extending their margin to as many as 44 points.
Lamar Wilkerson scored 18 of his 20 points in the second half for Indiana (17-10, 9-7), who lost its second straight to a top-10 team. The victory came three days after Purdue lost at home to top-ranked Michigan.