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The 26-year-old defender strained his flexor during the Parma warm-up, and his recovery is slower than planned. Consequently, manager Massimiliano Allegri may field Fikayo Tomori and Koni De Winter as the central defensive pair.
Ruben Loftus-Cheek and Santiago Gimenez also remain out injured. The Rossoneri aim to respond after their loss to Parma, which allowed league leaders Inter to extend their advantage at the top.